The BG-75 Biomarker Generator system integrates a 7.5 MeV cyclotron, Chemistry Production Module (CPM), and Quality Control Module (QCM) for on-site production of [18F]FDG, providing automated production and quality control testing. Both the cyclotron and chemistry modules are self-shielded, reducing radiation to <1 mR/hr at the minimum 5.5m x 5.5m room boundary.
Due to the system’s small footprint and self-shielding, the BG-75 Biomarker Generator can be easily incorporated into an existing clinical or research setting, adjacent to PET imaging equipment if needed. By contrast, standard PET biomarker laboratories produce batches of positron- emitting isotopes in a conventional medical cyclotron, which poses a far greater radiation burden requiring significant physical containment of both the cyclotron and all downstream processing steps. Typically, a concrete-re-inforced bunker is specially built to contain the cyclotron, with separate “hot” labs dedicated to radiochemistry and
QC, and several highly specialized staff to operate the cyclotron and perform the complex functions. In comparison, the BG-75 Biomarker Generator is scaled for a single engineer/operator, occupies one-tenth the space, requires little infrastructure modification, and has embedded chemistry and QC processes that greatly simplify the entire radiopharmaceutical production cycle.
These features translate into significantly less capital investment initially, and lower ongoing operating costs compared to conventional PET biomarker laboratories. Additionally, due to its self-contained design and lower energy, decommissioning the system at the end of its useful life is much simpler and far less costly. Overall, the total cost of ownership for the ABT BG-75 Biomarker Generator is less than one fourth that of conventional cyclotron solutions.